The ability to capture, organize, and analyze data is critical to health care organizations and to biomedical research. Database is arguably the most important tool in supporting data capture, organization, and analysis of outcomes, both for regular and transactional data as well as big data. This course will provide students with opportunities to learn data and big data management skills, including principles in database and approaches to manage data, as well as offer a place to discuss and analyze key issues in data management. The course will have two sections. The first section will emphasize the theoretical and technical aspects of database, specifically in data modeling, design of database, and learning the “language” to manage database. The second section will address advanced topics in database and big data, including transforming data, data warehousing and data mining, and analysis and visualization of data.