The ability to measure and describe issues in health informatics is vital to the process of decision-making in health care. The process of evaluation itself depends on the questions and the contexts in which the issue arises. This course will study the methods of evaluation in health informatics, specifically the practical application of well-established research and evaluation techniques to problems in health informatics. Different situations in health care will necessitate the use of different evaluation methods; therefore, in this course, students will be exposed to approaches to develop measurement instruments, design studies, analyze results, and present the results of the study in health informatics evaluations. Case studies will be used to facilitate active learning, including conducting usability evaluation and cost evaluation of health informatics resources. By the end of the course, students will be able to develop a working evaluation “contract,” which can be used to guide the evaluation process as well as to validate the result of the evaluation process itself (that the result is indeed what the stakeholders want and need to know to make a decision).