This course is a practical approach to understanding how patients present, learn and change based on the research on theories, models and techniques of: personality and learning styles; how to assess patient knowledge, attitude and readiness to change; and the effects of literacy, health literacy, individual coping mechanisms, ecological barriers and culture on patient comprehension and adherence. The use of validated interpersonal skills improves the clinician/patient relationship, demonstrates respect for the patient’s well-being and individuality, thereby reducing medical errors and lawsuits, and increasing patient adherence. Self-reflection on the student’s own barriers, biases, stereotypes, culture and assumptions is required. Assessment of understanding and skills will be conducted during the course as well as throughout the didactic program and clinical rotations.